Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease.

@article{Lawrance2001AlteredRO,
  title={Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease.},
  author={Ian Craig Lawrance and Lesley E. Maxwell and W Doe},
  journal={Inflammatory bowel diseases},
  year={2001},
  volume={7 3},
  pages={
          226-36
        }
}
BACKGROUND AND AIMS Fibrosis is a major complication of inflammatory bowel disease (IBD), which may be mediated by the intestinal fibroblast. Our aim was to isolate and characterize mucosal fibroblasts from histologically normal intestine (control), ulcerative colitis (UC), inflamed Crohn's disease (CD), and fibrosed CD intestine. METHODS Fibroblasts were characterized by light and electron microscopy and immunohistochemistry. Fibroblast collagen secretion and proliferation were determined by… CONTINUE READING

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