Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant

@article{Strazzullo2001AlteredRS,
  title={Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant},
  author={Pasquale Strazzullo and Roberto Iacone and Alfonso Siani and Gianvincenzo Barba and Ornella Russo and Paola Russo and Antonio Barbato and Lanfranco D'elia and Eduardo Farinaro and Francesco Paolo Cappuccio},
  journal={Journal of Molecular Medicine},
  year={2001},
  volume={79},
  pages={574-580}
}
A higher prevalence of hypertension has been associated with the G→A/GT (Gly40Ser) polymorphism of the glucagon receptor gene (GCGR) in two population studies. As the mutated receptor is less responsive to glucagon, it has been speculated that the increased susceptibility to hypertension is due to deprivation of the recognized natriuretic effect of the hormone. To test this hypothesis we determined the frequency of the polymorphic variant and evaluated the segmental renal sodium handling by the… CONTINUE READING