Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.

@article{Matsuoka2010AlteredRT,
  title={Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.},
  author={Ken-ichi Matsuoka and Haesook T Kim and Sean M McDonough and Gregory Bascug and Ben Warshauer and John Koreth and Corey S Cutler and Vincent Trien-Vinh Ho and Edwin P Alyea and Joseph H Antin and Robert J. Soiffer and Jerome Ritz},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 5},
  pages={1479-93}
}
CD4+CD25+Foxp3+ Tregs have an indispensable role in the maintenance of tolerance after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease (GVHD) have fewer circulating Tregs, but the mechanisms that lead to this deficiency of Tregs after HSCT are not known. Here, we analyzed reconstitution of Tregs and conventional CD4+ T cells (Tcons) in patients who underwent allogeneic HSCT after myeloablative conditioning. Following transplant, thymic generation of naive… CONTINUE READING

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Patients with chronic graft - versus - host disease ( GVHD ) have fewer circulating Tregs , but the mechanisms that lead to this deficiency of Tregs after HSCT are not known .
Patients with chronic graft - versus - host disease ( GVHD ) have fewer circulating Tregs , but the mechanisms that lead to this deficiency of Tregs after HSCT are not known .
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