Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic Goto-Kakizaki rats.

@article{Begum1998AlteredRO,
  title={Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic Goto-Kakizaki rats.},
  author={Najma Begum and Louis Ragolia},
  journal={Metabolism: clinical and experimental},
  year={1998},
  volume={47 1},
  pages={54-62}
}
We investigated the cellular mechanism(s) of insulin resistance associated with non-insulin-dependent diabetes mellitus (NIDDM) using adipocytes isolated from non-obese, insulin-resistant type II diabetic Goto-Kakizaki (GK) rats, a well-known genetic rat model for type II diabetic humans. In adipocytes isolated from control rats, insulin (5 nmol/L… CONTINUE READING