Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation.

@article{Aydar2003AlteredRO,
  title={Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation.},
  author={Y{\"u}ksel Aydar and P{\'e}ter Balogh and J. Grant Tew and Andras K. Szakal},
  journal={Journal of immunology},
  year={2003},
  volume={171 11},
  pages={5975-87}
}
Aging is associated with reduced trapping of Ag in the form of in immune complexes (ICs) by follicular dendritic cells (FDCs). We postulated that this defect was due to altered regulation of IC trapping receptors. The level of FDC-M1, complement receptors 1 and 2, FcgammaRII, and FDC-M2 on FDCs was immunohistochemically quantitated in draining lymph nodes… CONTINUE READING