Altered regulation of Escherichia coli biotin biosynthesis in BirA superrepressor mutant strains.

Abstract

Transcription of the Escherichia coli biotin (bio) operon is directly regulated by the biotin protein ligase BirA, the enzyme that covalently attaches biotin to its cognate acceptor proteins. Binding of BirA to the bio operator requires dimerization of the protein, which is triggered by BirA-catalyzed synthesis of biotinoyl-adenylate (biotinoyl-5'-AMP), the… (More)
DOI: 10.1128/JB.06549-11

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@article{Chakravartty2012AlteredRO, title={Altered regulation of Escherichia coli biotin biosynthesis in BirA superrepressor mutant strains.}, author={Vandana Chakravartty and John E. Cronan}, journal={Journal of bacteriology}, year={2012}, volume={194 5}, pages={1113-26} }