Altered red blood cell surface area in hereditary xerocytosis.

  title={Altered red blood cell surface area in hereditary xerocytosis.},
  author={N Sauberman and Grant A Fairbanks and Hans U. Lutz and Natalie Fortier and L. Michael Snyder},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={114 2-3},
Hereditary xerocytes appear larger than normal red cells in scanning electron micrographs and exhibit a higher ghost packing volume. The major chemical components--protein, phosphorus, cholesterol and sialic acid--are increased uniformly, as are all polypeptides visible on gel electrophoresis patterns of xerocyte membranes. These data are consistent with a xerocyte surface area 15 to 25% above normal. Certain clinical anomalies common to this disorder, including unexpectedly low reticulocyte… CONTINUE READING