Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer

@inproceedings{Nagaraj2007AlteredRO,
  title={Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer},
  author={Srinivas Nagaraj and Kapil Gupta and Vladimir Pisarev and Leo Kinarsky and Simon Sherman and Loveleen C. Kang and Donna Herber and Jonathan Schneck and Dmitry I Gabrilovich},
  year={2007}
}
1587 Antigen-specific CD8+ T-cell tolerance is one of the major mechanisms of tumor escape. Recent studies have shown that this tolerance was induced by myeloid-derived suppressor cells (MDSC). Using in vivo models we have found that MDSC directly disrupted the binding of the specific peptide-MHC dimers (pMHC) to CD8+ T cells via nitration of tyrosines within TCR/CD8 complex, which resulted in the inability of CD8+ T cells to bind pMHC and respond to the specific peptide. At the same time… CONTINUE READING

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