Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.

@article{Hasegawa2004AlteredPV,
  title={Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.},
  author={Jo Hasegawa and Klaus F. Wagner and D{\"o}rte Karp and Dechun Li and Junpei Shibata and Matthias Heringlake and Ludger Bahlmann and Reinhard Depping and Joachim Fandrey and Peter Schmucker and Stefan Uhlig},
  journal={American journal of respiratory and critical care medicine},
  year={2004},
  volume={169 7},
  pages={829-35}
}
Pulmonary vascular remodeling during chronic hypoxia may be the result of either oxygen deprivation or erythrocytosis. To separate experimentally the effects of hypoxia and erythrocytosis, we analyzed transgenic mice that constitutively overexpress the human erythropoietin gene in an oxygen-independent manner. These mice are characterized by polycythemia but have normal blood pressure, heart rate, and cardiac output. In transgenic mice, pulmonary artery pressure (PAP) was increased in vivo but… CONTINUE READING

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