Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.

  title={Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.},
  author={Jo Hasegawa and Klaus F. Wagner and D{\"o}rte Karp and Dechun Li and Junpei Shibata and Matthias Heringlake and Ludger Bahlmann and Reinhard Depping and Joachim Fandrey and Peter Schmucker and Stefan Uhlig},
  journal={American journal of respiratory and critical care medicine},
  volume={169 7},
Pulmonary vascular remodeling during chronic hypoxia may be the result of either oxygen deprivation or erythrocytosis. To separate experimentally the effects of hypoxia and erythrocytosis, we analyzed transgenic mice that constitutively overexpress the human erythropoietin gene in an oxygen-independent manner. These mice are characterized by polycythemia but have normal blood pressure, heart rate, and cardiac output. In transgenic mice, pulmonary artery pressure (PAP) was increased in vivo but… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Update on pulmonary hypertension complicating chronic obstructive pulmonary disease

International journal of chronic obstructive pulmonary disease • 2009
View 8 Excerpts
Highly Influenced

Pulmonary hypertension and chronic mountain sickness.

High altitude medicine & biology • 2013
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 40 references

Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 6 Excerpts
Highly Influenced

Altered pulmonary vascular reactivity in transgenic mice with excessive erythrocytosis [abstract

KF Wagner, J Hasegawa, +4 authors S. Uhlig
Am J Respir Crit Care Med • 2003
View 1 Excerpt

Routine renin-angiotensin system blockade in renal transplantation?

Current opinion in nephrology and hypertension • 2002
View 1 Excerpt

Similar Papers

Loading similar papers…