Altered pulmonary function in children with asthma associated with highway traffic near residence

@article{Margolis2009AlteredPF,
  title={Altered pulmonary function in children with asthma associated with highway traffic near residence},
  author={Helene G. Margolis and Jennifer K. Mann and Fred Lurmann and Kathleen M. Mortimer and John R. Balmes and Sally Katharine Hammond and Ira B. Tager},
  journal={International Journal of Environmental Health Research},
  year={2009},
  volume={19},
  pages={139 - 155}
}
Cross-sectional analyses were conducted to evaluate the effects of exposure to highway traffic on pulmonary function in Fresno, California. Traffic and spirometry data were available for 214 children (enrollment ages six to 11 years). Multiple linear regression was used to evaluate the relations between pulmonary function and traffic parameters. Heavy-duty vehicle count was used as a surrogate measure for diesel-related exposures. Pulmonary function was non-significantly associated with longer… 
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References

SHOWING 1-10 OF 29 REFERENCES
ROAD TRAFFIC, NO2 EXPOSURE AND RESPIRATORY FUNCTION AMONG CHILDREN (VESTA STUDY)
Within the multicentre VESTA case-control study on childhood asthma and traffic air pollution, we studied the association between the respiratory function and NO2 personal exposures or intensity of
Air Pollution from Truck Traffic and Lung Function in Children Living near Motorways
TLDR
Results indicate that exposure to traffic‐related air pollution, in particular diesel exhaust particles, may lead to reduced lung function in children living near major motorways.
Effects of asthma on pulmonary function in children. A longitudinal population-based study.
TLDR
It is predicted that a female who develops asthma at age 7 would experience a 5% reduction in FEV1 by age 10 and a 7% deficit by age 15, and from this analysis, it would predict that a male who develops asthmatic disease at age 9 would experience an 8% deficit.
Sex-specific effects of asthma on pulmonary function in children.
TLDR
Results are consistent with prior evidence that lung function deficits in children with asthma persist into adulthood and suggest that in children, commonly observed differences between sexes in the impact of asthma on lung function may reflect differences in the duration and age of onset of asthma in males and females.
The effect of air pollution on lung development from 10 to 18 years of age.
TLDR
Current levels of air pollution have chronic, adverse effects on lung development in children from the age of 10 to 18 years, leading to clinically significant deficits in attained FEV as children reach adulthood.
Traffic-Related Air Pollution Affects Peak Expiratory Flow, Exhaled Nitric Oxide, and Inflammatory Nasal Markers
TLDR
Urban children had increased levels of inflammatory nasal markers, and their responses were more pronounced than were the suburban children's responses to the same increments of air pollution.
Road tunnel air pollution induces bronchoalveolar inflammation in healthy subjects
TLDR
Exposure of healthy subjects to traffic-related air pollution resulted in a lower airway inflammatory response with cell migration, together with signs of an initiated signal transduction in the bronchial epithelium.
Effects on respiratory health of a reduction in air pollution from vehicle exhaust emissions
TLDR
The by-pass reduced pollutant levels to a degree that probably alleviates rhinitis and rhinoconjunctivitis but has little effect on lower respiratory symptoms.
Evaluating the use of a portable spirometer in a study of pediatric asthma.
STUDY OBJECTIVES Laboratory-based spirometry is the "gold standard" for the assessment of lung function, both in clinical and research protocols. These spirometers, however, are neither practical nor
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