Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).

@article{Hashimoto2001AlteredPB,
  title={Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).},
  author={Hitoshi Hashimoto and Norihito Shintani and Kiyoji Tanaka and Wakaba Mori and Mayumi Hirose and Takayoshi Matsuda and Masaki Sakaue and Jun-Ichi Miyazaki and Hitoshi Niwa and Fumi Tashiro and Kazuo Yamamoto and Kazumi Koga and Shuhei Tomimoto and Akiyoshi Kunugi and Sayoko Suetake and A. Ramesha Baba},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 23},
  pages={13355-60}
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain. In Drosophila, mutation of the PACAP homologue results in behavioral defects, including impaired olfaction-associated learning and changes in ethanol sensitivity. Here, we report the generation of mice lacking the PACAP gene (PACAP(-/-)). PACAP(-/-) mice were born in the expected Mendelian ratios but had a high early-mortality rate. The… CONTINUE READING
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