Altered proline uptake by mouse liver cells after chronic exposure to ethanol and its metabolites.

A cloned mouse liver cell model (NCTC 1469) treated with either ethanol or one of its metabolites, acetaldehyde or acetate, was used to study proline uptake. Beginning with the stationary phase of cell growth, 14C-proline uptake was markedly accelerated by both ethanol and acetaldehyde (p less than 0.001). When ethanol treatment was combined with 4-methyl… CONTINUE READING