Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice

@inproceedings{Andrews2016AlteredPA,
  title={Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice},
  author={William D Andrews and Kathryn Davidson and Nobuaki Tamamaki and Christiana Ruhrberg and John G. Parnavelas},
  booktitle={The Journal of comparative neurology},
  year={2016}
}
Cortical interneurons are generated predominantly in the medial ganglionic eminence (MGE) and migrate through the ventral and dorsal telencephalon before taking their final positions within the developing cortical plate. Previously we demonstrated that interneurons from Robo1 knockout (Robo1(-/-)) mice contain reduced levels of neuropilin 1 (Nrp1) and PlexinA1 receptors, rendering them less responsive to the chemorepulsive actions of semaphorin ligands expressed in the striatum and affecting… CONTINUE READING
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