Altered proliferation of alveolar epithelial cells is involved in progressive elastase-induced emphysema

@inproceedings{Bohla2012AlteredPO,
  title={Altered proliferation of alveolar epithelial cells is involved in progressive elastase-induced emphysema},
  author={Alexander Bohla and Katrin Kohse and Johannes Schwarz and G Zabolitzky John and Oana Veronica Amarie and Oliver Eickelberg and Ali Oender Yildirim},
  year={2012}
}
RATIONALE: Chronic obstructive pulmonary disease (COPD) is characterized amongst others by development of emphysema. We showed that a single application of porcine pancreatic elastase (PPE) causes a severe progressing emphysema-like phenotype in C57BL/6 mice. Since the development of emphysema is apparently not completed after PPE application, we aimed to identify possible key mechanisms that drive this process even at late time points. METHODS: Female C57BL/6 mice received a single… CONTINUE READING

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