Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome.

@article{Tana2010AlteredPO,
  title={Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome.},
  author={Chunyan Tana and Yoshinori Umesaki and Akemi Imaoka and Tomohiro Handa and Motoyori Kanazawa and Shin Fukudo},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2010},
  volume={22 5},
  pages={512-9, e114-5}
}
BACKGROUND The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids. METHODS Subjects were 26 IBS patients and 26 age- and sex-matched controls. Fecal samples were collected for microbiota analysis using quantitative real-time polymerase chain reaction and culture methods, and the… CONTINUE READING
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Novel and specific roles for the inon channel TRPA1 in visceral sensory transduction

  • SM Brierley, PA Hughes, AJ Page
  • Gastroenterology 2008; 134(Suppl
  • 2008

Alteration in the brain–gut axis underlying visceral hypersensitivity in Nippostrongylus brasilinensis-infected mice

  • J Aerssens, K Hillsley, PJ Peeters
  • Gastroenterology
  • 2007

Group - specific PCR primers for the detection of human intestinal bacte

  • T Matsuki, J Fujimoto, K Watanabe
  • Japanese patent
  • 2007

The feacal microbiota of irritable bowel syndrome patients differs significantly from that of health subjects

  • A Kassinen, L Kroqius-Kurikka, H Mökivuokko
  • 2007

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