Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome.

  title={Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome.},
  author={Chunyan Tana and Yoshinori Umesaki and Akemi Imaoka and Tomohiro Handa and Motoyori Kanazawa and Shin Fukudo},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  volume={22 5},
  pages={512-9, e114-5}
BACKGROUND The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids. METHODS Subjects were 26 IBS patients and 26 age- and sex-matched controls. Fecal samples were collected for microbiota analysis using quantitative real-time polymerase chain reaction and culture methods, and the… CONTINUE READING
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