Altered potassium channel function in the superficial dorsal horn of the spastic mouse.

@article{Graham2007AlteredPC,
  title={Altered potassium channel function in the superficial dorsal horn of the spastic mouse.},
  author={Brett Anthony Graham and Alan M. Brichta and Peter R. Schofield and Robert John Callister},
  journal={The Journal of physiology},
  year={2007},
  volume={584 Pt 1},
  pages={121-36}
}
The spastic mouse has a naturally occurring glycine receptor (GlyR) mutation that disrupts synaptic input in both motor and sensory pathways. Here we use the spastic mouse to examine how this altered inhibitory drive affects neuronal intrinsic membrane properties and signal processing in the superficial dorsal horn (SDH), where GlyRs contribute to pain processing mechanisms. We first used in vitro patch clamp recording in spinal cord slices (L3-L5 segments) to examine intrinsic membrane… CONTINUE READING

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