Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury.

Abstract

Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after… (More)
DOI: 10.7554/eLife.12661

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