Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats.

@article{Garrido1999AlteredPA,
  title={Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats.},
  author={Mar{\'i}a Jes{\'u}s Garrido and Mercedes del Valle and Rosario Calvo and I{\~n}aki F. Troc{\'o}niz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={288 1},
  pages={
          179-87
        }
}
The pharmacokinetics and pharmacodynamics of methadone were investigated in control and abstinent rats. Minipumps filled with saline (control group) or saline-morphine (abstinent group) solutions were used to induce physical dependence. Solutions were delivered continuously by minipumps for 6 days. The physical dependence was evaluated 12 h after minipump removal by measuring specific withdrawal signs. Animals from the abstinent group showed clear withdrawal signs such as hostility on handling… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-9 of 9 citations