Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

@article{Chackalaparampil1988AlteredPA,
  title={Altered phosphorylation and activation of PP60c-src during fibroblast mitosis},
  author={Isaac Chackalaparampil and David Shalloway},
  journal={Cell},
  year={1988},
  volume={52},
  pages={801-810}
}
At least half the pp60c-src in NIH 3T3-derived c-src overexpresser cells in modified by novel threonine and, possibly, serine phosphorylation within its amino 16 kd region during mitosis. At the same time, the tryptic phosphopeptide containing Ser 17, the site of cyclic AMP-dependent phosphorylation, is either modified or dephosphorylated. While the amount of pp60c-src is not significantly altered, the in vitro-specific kinase activity of modified pp60c-src is enhanced 4- to 7-fold. Modified… CONTINUE READING
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