Altered phenotype of regulatory T cells associated with lack of human immunodeficiency virus (HIV)-1-specific suppressive function.

@article{Burton2011AlteredPO,
  title={Altered phenotype of regulatory T cells associated with lack of human immunodeficiency virus (HIV)-1-specific suppressive function.},
  author={C. T. P. Burton and Samantha Jane Westrop and Ijeoma G. Eccles-James and Adriano Boasso and Mark Richard Nelson and Mark Bower and Nesrina Imami},
  journal={Clinical and experimental immunology},
  year={2011},
  volume={166 2},
  pages={
          191-200
        }
}
Mechanisms by which CD4+ regulatory T cells (T(regs)) mediate suppression of virus-specific responses remain poorly defined. Adenosine, mediated via CD39 and CD73, has been shown to play a role in the action of murine T(regs) . In this study we investigate the phenotype of T(regs) in the context of human immunodeficiency virus (HIV)-1 infection, and the function of these cells in response to HIV-1-Gag and cytomegalovirus (CMV) peptides. Phenotypic data demonstrate a decrease in forkhead box… CONTINUE READING
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