Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice.

  title={Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice.},
  author={J. van Asperen and Alfred H Schinkel and Jos H. Beijnen and Willem J. Nooijen and Piet Borst and Olaf van Tellingen},
  journal={Journal of the National Cancer Institute},
  volume={88 14},
BACKGROUND P-glycoprotein (Pgp) is a membrane protein that acts as an extrusion pump for many cytotoxic drugs. Pgp is expressed in normal tissues, and its (over)expression in tumor cells contributes to their drug resistance. Human Pgp is encoded by the MDR1 gene, In mice, two Pgps (encoded by the mdr1a and mdr1b genes) appear to perform the same function as the single human protein. The simultaneous use of cytotoxic drugs and agents that block Pgp function has raised questions of safety, since… CONTINUE READING
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