Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats.

@article{Choi2006AlteredPO,
  title={Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats.},
  author={Byung-Chul Choi and Jun-shik Choi and Hyo-Kyung Han},
  journal={International journal of pharmaceutics},
  year={2006},
  volume={323 1-2},
  pages={81-5}
}
The purpose of this study was to investigate the effect of morin on the pharmacokinetics of orally and intravenously administered paclitaxel in rats. Pharmacokinetic parameters of paclitaxel were determined in rats after an oral (30 mg kg(-1)) or intravenous (3 mg kg(-1)) administration of paclitaxel to rats in the presence and absence of morin (3.3 and 10 mg kg(-1)). Compared to the control given paclitaxel alone, pretreatment with morin 30 min prior to the oral administration of paclitaxel… CONTINUE READING

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