Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia/reperfusion-induced acute kidney injury.

@article{Matsuzaki2008AlteredPO,
  title={Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia/reperfusion-induced acute kidney injury.},
  author={Takanobu Matsuzaki and Takafumi Morisaki and Wakako Sugimoto and Koji Yokoo and Daisuke Sato and Hiroshi Nonoguchi and Kimio Tomita and Tomohiro Terada and Ken-ichi Inui and Akinobu Hamada and Hideyuki Saito},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 4},
  pages={649-54}
}
In the proximal tubules of rat (r) kidney, the polyspecific organic cation transporters (OCTs), rOCT1 and rOCT2, mediate the baso-lateral uptake of various organic cations, including many drugs, toxins, and endogenous compounds, and the apical type of H(+)/ organic cation antiporter, rat multidrug and toxin extrusion 1 (rMATE1), mediate the efflux of organic cations. Renal clearances of H(2) receptor antagonists, including famotidine, were reported to be decreased in patients with kidney… CONTINUE READING
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