• DOI:10.1080/107175401316906883
Corpus ID: 2356254

Altered pharmacokinetics and liver targetability of methotrexate by conjugation with lactosylated albumins.

@article{Han2001AlteredPA,
  title={Altered pharmacokinetics and liver targetability of methotrexate by conjugation with lactosylated albumins.},
  author={Junghee Han and Su Jeung Lim and Min Kyung Lee and C K Kim},
  journal={Drug delivery},
  year={2001},
  volume={8 3},
  pages={
          125-34
        }
}

Junghee Han, Su Jeung Lim, +1 author C K Kim

Published in Drug delivery 2001

Chemistry, Medicine

To enhance the liver targetability, methotrexate (MTX) was conjugated with albumin previously substituted with varying content of lactose (L0, L5, and L24). The uptake of MTX by rat hepatocytes in vitro increased according to the increase in the lactose content on the albumin conjugates. The MTX level in the plasma and various organs was determined by counting the radioactivity of [3H]MTX and by HPLC assay, separately, to monitor the in vivo fate of MTX not only as total, regardless of forms of… CONTINUE READING

View on PubMed

tandfonline.com

Save to Library

Create Alert

Cite

Launch Research Feed