Altered pharmacokinetics and hepatic uptake of TBuMA in ethynylestradiol-induced cholestasis.

Abstract

The objective of this study was to examine the pharmacokinetics of organic cations in intrahepatic cholestatic rats. A pretreatment with 17alpha-ethynylestradiol was used to induce intrahepatic cholestasis, and tributylmethylammonium (TBuMA) was used as a representative model organic cation. When [3H]TBuMA was intravenously administered1 the AUC value for… (More)

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Cite this paper

@article{Hong2006AlteredPA, title={Altered pharmacokinetics and hepatic uptake of TBuMA in ethynylestradiol-induced cholestasis.}, author={Soon-Sun Hong and Jong-Moon Choi and Hyo-Eon Jin and Chang-koo Shim}, journal={Archives of pharmacal research}, year={2006}, volume={29 4}, pages={323-7} }