Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride.


The disappearance curves of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the circulating blood were divided into three different phases, K1, K2 and K3 after its intravenous administration to rats. The relationship between the activity of liver microsomal drug-metabolizing enzymes and K3 values, which were obtained by measuring FT-207 levels between 5… (More)


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