Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.

@article{Smyth1998AlteredPL,
  title={Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.},
  author={Lesley Ann Smyth and Owen Williams and Russell D. J. Huby and Trisha Norton and Oreste Acuto and Steven C. Ley and Dimitris Kioussis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 14},
  pages={8193-8}
}
Interaction of the T cell receptor (TCR) with peptide/major histocompatibility complexes (MHC) in the thymus is of critical importance for developing thymocytes. In a previous study, we described an antagonist peptide that inhibited negative selection of transgenic thymocytes induced by an agonist peptide. In this study we show that this antagonist peptide can induce positive selection of CD8(+) thymocytes more efficiently than the agonist or the weak agonist peptides, whereas the opposite is… CONTINUE READING

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Smyth et al

  • C.R.F. Monks, H. Kupfer, +4 authors 83–86. 8198 Immunology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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