Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy.

@article{Houser1990AlteredPO,
  title={Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy.},
  author={Carolyn R. Houser and J E Miyashiro and Barbara Swartz and Gregory O Walsh and Jamie R. Rich and Antonio V Delgado-Escueta},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1990},
  volume={10 1},
  pages={267-82}
}
Dynorphin A(1-17), an opioid peptide that is normally present in the hippocampal mossy fiber system, was localized immunocytochemically in the hippocampal formation of control autopsy and temporal lobe epilepsy (TLE) specimens. In control tissue, dynorphin-like immunoreactive (Dyn-IR) structures were confined to the mossy fiber path and were most highly concentrated in the polymorph (hilar) region of the dentate gyrus. Very few Dyn-IR structures were present in the molecular and granule cell… CONTINUE READING
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