Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest.

@article{Ciarallo2002AlteredPP,
  title={Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest.},
  author={Sandra Ciarallo and Venkateswaran Subramaniam and Wesley J Hung and J Lee and Rouslan Kotchetkov and Charanjit Sandhu and Andrea Milic and Joyce M Slingerland},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 9},
  pages={2993-3002}
}
p27(Kip1) is an important effector of G(1) arrest by transforming growth factor beta (TGF-beta). Investigations in a human mammary epithelial cell (HMEC) model, including cells that are sensitive (184(S)) and resistant (184A1L5(R)) to G(1) arrest by TGF-beta, revealed aberrant p27 regulation in the resistant cells. Cyclin E1-cyclin-dependent kinase 2 (cdk2) and cyclin A-cdk2 activities were increased, and p27-associated kinase activity was detected in 184A1L5(R) cells. p27 from 184A1L5(R) cells… CONTINUE READING

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