Altered oxidative stress profile in the cortex of mice fed an enriched branched-chain amino acids diet: possible link with amyotrophic lateral sclerosis?

@article{Piscopo2011AlteredOS,
  title={Altered oxidative stress profile in the cortex of mice fed an enriched branched-chain amino acids diet: possible link with amyotrophic lateral sclerosis?},
  author={Paola Piscopo and Alessio Crestini and Alice Adduci and Antonella Ferrante and Maddalena Massari and Patrizia Popoli and Nicola Vanacore and Annamaria Confaloni},
  journal={Journal of neuroscience research},
  year={2011},
  volume={89 8},
  pages={1276-83}
}
Branched-chain amino acids (BCAAs), valine, isoleucine, and leucine, are widely used among athletes as dietary integrators. Although the occurrence of untoward effects of BCCA supplementation, with particular regard to neurological disturbances, cannot be excluded, no specific studies have been performed so far. The aim of this work was to evaluate the effects of a diet enriched in BCAAs on the expression of oxidative stress pathway genes in the brain of C57Bl/6J mice. Animals were fed a… CONTINUE READING