Altered norepinephrine regulation in bulimia: Effects of pharmacological challenge with isoproterenol

@article{George1990AlteredNR,
  title={Altered norepinephrine regulation in bulimia: Effects of pharmacological challenge with isoproterenol},
  author={David T. George and Walter H. Kaye and David S. Goldstein and Timothy D. Brewerton and David C. Jimerson},
  journal={Psychiatry Research},
  year={1990},
  volume={33},
  pages={1-10}
}
While abnormalities in central norepinephrine regulation may contribute to abnormal eating patterns in bulimia nervosa, alterations in function of the peripheral sympathetic nervous system could contribute to the decreased metabolic rate and increased anxiety responses previously reported in these patients. To assess beta-adrenergic receptor sensitivity in bulimic patients, we studied cardiovascular and hormonal responses to acute pharmacological challenge with intravenously administered… 
Behavioral Responses to Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa and Healthy Subjects
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Serotonin and Norepinephrine Activity in Anorexia and Bulimia Nervosa: Relationship to Nutrition, Feeding, and Mood
Anorexia and bulimia nervosa (DSM-III-R, 1987) are disorders of unknown etiology which are characterized by alterations of appetitive behavior and distortions of body image. Eating disorder patients
Reboxetine in a patient with seasonal bulimia resistant to SSRIs and light therapy.
TLDR
The case of a woman who suffered from seasonal affective disorder and nonpurging bulimia nervosa for 16 years and was resistant to treatment regimens with selective serotonin re-uptake inhibitors and bright light therapy is described.
Reboxetine in a patient with seasonal bulimia resistant to SSRIs and light therapy.
TLDR
The case of a woman who suffered from seasonal affective disorder and nonpurging bulimia nervosa for 16 years and was resistant to treatment regimens with selective serotonin re-uptake inhibitors and bright light therapy is described.
Reboxetine in a patient with seasonal bulimia resistant to SSRIs and light therapy
There is a phenomenological similarity between seasonal affective disorder and bulimia nervosa, as sufferers from both show increased appetite and carbohydrate craving and probably share a common
Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans
TLDR
Evidence for the efficacy of monoaminergic treatments for anorexia nervosa is limited, while more support exists for the treatment of BN or BED with Monoaminergic drugs.
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References

SHOWING 1-10 OF 29 REFERENCES
State-related changes in norepinephrine regulation in anorexia nervosa
TLDR
Urinary excretion of the major norepinephrine metabolite 3-me~oxy-4-hy~xphenyle~ylene glycol (MHPG) was low in a group of depressed anorexic patients, and Biederman et al. (1984) reported that urinary excretion in plasma and urine was low.
Disturbances of noradrenergic systems in normal weight bulimia: Relationship to diet and menses
TLDR
This study confirms that reduced noradrenergic activity occurs in normal-weight bulimic women and suggests that this abnormality may emerge during abstinence from bingeing, and hypothesizes that dietary intake is related to noradRenergic activity, but cause and effect remain uncertain.
Reduced resting metabolic rate in patients with bulimia nervosa.
TLDR
Energy expenditure measurements were made in 15 women with bulimia nervosa during abstinence from bingeing and vomiting to determine whether there was a metabolic basis for reports that bulimic patients had low energy requirements for weight maintenance.
Beta2-adrenergic receptor regulation in circulating mononuclear leukocytes in anorexia nervosa and bulimia
Abstract Mononuclear leukocyte (MNL) β 2 -adrenergic receptors and their coupled adenylate cyclase system were studied in underweight anorectics ( n = 12), weight-recovered anorectics ( n = 8),
Comparison of lactate-induced anxiety in bulimic patients and healthy controls
TLDR
Bulimic patients had significantly elevated anxiety ratings at baseline, and showed a trend toward greater increases in anxiety ratings after lactate administration, and none of the bulimic subjects experienced a panic attack during lactate infusion.
Lymphocyte β-Adrenergic Receptor Modification in Bulimia
• β-Adrenergic receptor binding on circulating lymphocytes was evaluated in young female bulimic patients (n =12) and age- and sex-matched normal control volunteers (n =10). Using iodine 125—labeled
Metabolic and endocrine indices of starvation in Bulimia: A comparison with anorexia nervosa
TLDR
Data indicate that many patients with bulimia showed the metabolic signs of starvation at the time of the study, a finding supported by the symptoms of endocrine adaptation to starvation, namely low triiodothyronine and a decreased noradrenaline response to an orthostatic test in many of these patients.
Relationship of mood alterations to bingeing behaviour in bulimia.
TLDR
Bingeing and vomiting episodes may provide bulimic patients with a physiological mechanism for temporarily relieving a dysphoric mood state, and both subjective and objective ratings of mood indicated that anxiety decreased more frequently and to a greater extent than depression, both during and after bingeing and vomit.
Platelet α2-Adrenoceptor and Adenylate Cyclase in Patients with Anorexia Nervosa and Bulimia
TLDR
In patients with bulimia or anorexia nervosa, both initially and after weight gain, the maximal effect of prostaglandin E1 (PGE1) on platelet cAMP production was greatly increased, while the half-maximally effective dose was unchanged.
Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers.
TLDR
A large number of patients with bulimic patients were assessed daily for body weight, caloric intake, macronutrient diet content, activity measures, and body composition estimates during weight-stable periods to support patient complaints of a tendency to gain weight easily.
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