Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

@article{Felipe1998AlteredNA,
  title={Altered nociception, analgesia and aggression in mice lacking the receptor for substance P},
  author={C. Felipe and J. F. Herrero and J. O'Brien and J. Palmer and C. A. Doyle and A. J. Smith and J. Laird and C. Belmonte and F. Cerver{\'o} and S. Hunt},
  journal={Nature},
  year={1998},
  volume={392},
  pages={394-397}
}
The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system. Substance P is synthesized by small-diameter sensory ‘pain’ fibres, and release of the peptide into the dorsal horn of the spinal cord following intense peripheral stimulation promotes central hyperexcitability and increased sensitivity to pain. However, despite the availability of… Expand
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1
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3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
Opiate analgesics inhibit substance P release from rat trigeminal nucleus
Distribution of the substance P receptor (NK-1 receptor) in the central nervous system.
Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.
Gene regulation in an ascending nociceptive pathway: inflammation- induced increase in preprotachykinin mRNA in rat lamina I spinal projection neurons
  • K. Noguchi, M. Ruda
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992
...
1
2
3
...