Altered neurovascular control of the resting circulation in human metabolic syndrome.

@article{Limberg2012AlteredNC,
  title={Altered neurovascular control of the resting circulation in human metabolic syndrome.},
  author={Jacqueline K. Limberg and Barbara J Morgan and Joshua J. Sebranek and Lester T. Proctor and Benjamin J. Walker and Marlowe W. Eldridge and William G Schrage},
  journal={The Journal of physiology},
  year={2012},
  volume={590 23},
  pages={6109-19}
}
Young healthy adults exhibit an inverse linear relationship between muscle sympathetic nerve activity (MSNA) and α-adrenergic responsiveness. This balance may be reversed in metabolic syndrome (MetSyn) as animal models exhibit increased sympathetic activity and α-mediated vasoconstriction. We hypothesized humans with MetSyn would demonstrate increased α-adrenergic vasoconstriction and the inverse relationship between MSNA and adrenergic responsiveness would be lost. We measured MSNA… CONTINUE READING