Altered neurotrophin receptor function in the developing prefrontal cortex leads to adult-onset dopaminergic hyperresponsivity and impaired prepulse inhibition of acoustic startle.

@article{Rajakumar2004AlteredNR,
  title={Altered neurotrophin receptor function in the developing prefrontal cortex leads to adult-onset dopaminergic hyperresponsivity and impaired prepulse inhibition of acoustic startle.},
  author={Nagalingam Rajakumar and L. Stan Leung and Jintang Ma and Banerjee Rajakumar and Walter J. Rushlow},
  journal={Biological psychiatry},
  year={2004},
  volume={55 8},
  pages={797-803}
}
BACKGROUND Survival and differentiation of neurons and the formation and maintenance of synapses in the cerebral cortex may be affected in schizophrenia. Since neurotrophins play an important role in these events, behavioral effects relevant to schizophrenia were investigated in rats that had compromised neurotrophin function during prefrontal cortical development. METHODS Neonatal rat pups were injected into the developing prefrontal cortex with a depot preparation of p75 receptor antibody… CONTINUE READING