Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis.

@article{Micera1999AlteredNG,
  title={Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis.},
  author={Alessandra Micera and Alessandro Lambiase and Paolo Rama and Luigi Aloe},
  journal={Multiple sclerosis},
  year={1999},
  volume={5 6},
  pages={389-94}
}
In this study we measured with a highly sensitive two-site immunoenzymatic assay the levels of nerve growth factor (NGF) in human optic nerve affected by multiple sclerosis (MS). The result of this study showed an elevated increase of NGF in the MS optic nerves, as compared to the level of NGF found in the optic nerves non-affected by this demyelinating disorder. Moreover, the results showed that the optic nerves also expressed trkA NGF receptor and NGFmRNA, most likely by oligodendrocytes… CONTINUE READING