Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study.

@article{Altamura2007AlteredNC,
  title={Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study.},
  author={Claudia Altamura and Maria Luisa Dell'Acqua and Rainald Moessner and Dennis L. Murphy and Klaus-Peter Lesch and Antonio M Persico},
  journal={Cerebral cortex},
  year={2007},
  volume={17 6},
  pages={1394-401}
}
The neurotransmitter serotonin (5-HT) plays morphogenetic roles during development, and their alteration could contribute to autism pathogenesis in humans. To further characterize 5-HT's contributions to neocortical development, we assessed the thickness and neuronal cell density of various cerebral cortical areas in serotonin transporter (5-HTT) knockout (ko) mice, characterized by elevated extracellular 5-HT levels. The thickness of layer IV is decreased in 5-HTT ko mice compared with wild… CONTINUE READING

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