Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression.

@article{Rizzo2012AlteredNK,
  title={Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression.},
  author={Roberta Rizzo and Valentina Gentili and Ilaria Casetta and Elisabetta Caselli and Riccardo De Gennaro and Enrico Granieri and Enzo Cassai and Dario Di Luca and Antonella Rotola},
  journal={Journal of neuroimmunology},
  year={2012},
  volume={251 1-2},
  pages={55-64}
}
The role of herpes viruses as potential triggers of multiple sclerosis (MS) is still debated. Peripheral blood mononuclear cells from MS patients and controls were treated with CpG sequences and infected in vitro with HSV-1. Samples were analyzed for viral yield, TLR9 pathways, cytokine secretion, NK cell activation and killer immunoglobulin-like receptor (KIR) expression. CpG treatment promoted an unexpected sensitivity to herpes virus infection in a subset of MS patients: TLR9 pathways did… CONTINUE READING