Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident

  title={Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident},
  author={David M. Goldenberg and Mariano Russo and Kenneth R Houser and Henry Crist and Jonathan B Derr and Vonn Walter and Joshua I Warrick and Kathryn E Sheldon and James R. Broach and Darrin V Bann},
  journal={The Laryngoscope},
In 1979, Three Mile Island (TMI) nuclear power plant experienced a partial meltdown with release of radioactive material. The effects of the accident on thyroid cancer (TC) in the surrounding population remain unclear. Radiation‐induced TCs have a lower incidence of single nucleotide oncogenic driver mutations and higher incidence of gene fusions. We used next generation sequencing (NGS) to identify molecular signatures of radiation‐induced TC in a cohort of TC patients residing near TMI during… 

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in

Rising Thyroid Cancer Incidence Proximate to a New York City-Area Nuclear Power Plant

Thyroid cancer incidence has risen steadily in the US for several decades. While any cause of this trend has yet to be clearly identified, most analyses have concluded that there are factors other

Detection of Genomic Alterations Caused by Low-Dose Γ-Irradiation in Human Normal Fibroblast Cells

  • Yoshiharu Tanaka
  • Medicine
    Biomedical Journal of Scientific & Technical Research
  • 2019
The effects of Low-Dose Radiation (LDR) on human health are still debated, despite LDR being ubiquitous in our environment, such as via radioactive substance leakage following an accident at a

High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis

The different BRAF statuses in coincident thyroid carcinoma foci within the same organ outline a special challenge for molecular follow-up and therapeutic decision-making.

Inadvertent Radiation Exposures in Combat Zones: Risk of Contamination and Radiobiologic Consequences.

On February 24, 2022, Russia began a military invasion of Ukraine. Missile and air strikes were reported throughout the country, shortly followed by a large ground invasion from multiple directions.

The unsustainable legacy of the Nuclear Age.

It is seldom acknowledged the tremendous burden that the Nuclear Age leaves on future generations, and the environment, for an extremely long time. Nuclear processes, and products, are activated at

The Cosmology of Evidence: Suffering, Science, and Biological Witness After Three Mile Island

  • M. Mitchell
  • Political Science
    Journal of the history of biology
  • 2021
This article traces intertwined networks of activists from Japan and Pennsylvania as they mobilized legally, politically, and scientifically to develop evidence about the offsite effects of Three Mile Island, and shows how they placed the messy, contingent, dynamic living world at the center of inquiries about the meltdown’s consequences.



Incidence of thyroid cancer surrounding three mile island nuclear facility: The 30‐year follow‐up

If data 30 years later will change original conclusions, explore thyroid cancer incidence rates near nuclear power plants, and better understand effects of chronic low level radiation are explored.

Incidence of Thyroid Cancer in Residents Surrounding the Three Mile Island Nuclear Facility

Given the long latency period for the development of thyroid cancer after exposure to low‐level radiation exposure, it is plausible that an increase in thyroid cancer incidence might just now be occurring.

RET/PTC and PAX8/PPARγ chromosomal rearrangements in post‐Chernobyl thyroid cancer and their association with iodine‐131 radiation dose and other characteristics

Childhood exposure to iodine‐131 from the 1986 nuclear accident in Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data

Radiation-induced thyroid cancer: What we have learned from Chernobyl

It is revealed that environmental exposure to 131l during childhood carries an increased risk of thyroid cancer and the risk is radiation dose dependent, the youngest children are most sensitive to radiation-induced carcinogenesis, and the minimal latent period for thyroid cancer development after exposure is as short as 4 yr.

Incidence of thyroid cancer surrounding Three Mile Island nuclear facility: the 30-year follow-up.

Thyroid cancer incidence since the TMI accident was greater than expected in the counties analyzed when compared to local and national population growth, which supports a link to chronic low level radiation exposure and thyroid cancer development.

Low frequency of BRAF mutations in adult patients with papillary thyroid cancers following childhood radiation exposure.

There is a similar low frequency of BRAF mutations among a cohort of those exposed to external beam radiation as children who later developed papillary thyroid cancer as adults, further evidence that BRAF mutated cancers are rare events in cancers seen in subjects exposed to radiation asChildren.

High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident.

Intrachromosomal rearrangement involving RET and the adjacent H4 or ELE gene on chromosome no. 10 is a very frequent event in thyroid cancer of children of the Chernobyl-contaminated zone of Belarus.

The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose

It is found that the log‐transformed radiation dose and latency period were independently associated with the BRAFV600E mutation, and results suggest that involvement of BRAF mutation in thyroid carcinogenesis in exposed people may differ from that in the nonexposed people.

Copy number and gene expression alterations in radiation-induced papillary thyroid carcinoma from chernobyl pediatric patients.

Comparative genomic hybridization allows an assessment of gene expression changes that are associated with a physical mechanism and these genes and chromosomal regions are potential markers for radiation-induced PTC.

High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation

The results confirm the crucial role played by the ret proto-oncogene activating rearrangements in the development of radiation-associated thyroid tumors appearing after therapeutic or accidental ionizing irradiation, and show, for the first time, the presence of RET/PTC genes in follicular adenomas appeared after external irradiation.