Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident

@article{Goldenberg2017AlteredMP,
  title={Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident},
  author={David M. Goldenberg and Mariano Russo and Kenneth R Houser and Henry Crist and Jonathan B Derr and Vonn Walter and Joshua I Warrick and Kathryn E Sheldon and James R. Broach and Darrin V Bann},
  journal={The Laryngoscope},
  year={2017},
  volume={127}
}
In 1979, Three Mile Island (TMI) nuclear power plant experienced a partial meltdown with release of radioactive material. The effects of the accident on thyroid cancer (TC) in the surrounding population remain unclear. Radiation‐induced TCs have a lower incidence of single nucleotide oncogenic driver mutations and higher incidence of gene fusions. We used next generation sequencing (NGS) to identify molecular signatures of radiation‐induced TC in a cohort of TC patients residing near TMI during… 

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