Altered molecular pathways in gliomas: an overview of clinically relevant issues.

@article{Rao2004AlteredMP,
  title={Altered molecular pathways in gliomas: an overview of clinically relevant issues.},
  author={Ravi D. Rao and C. David James},
  journal={Seminars in oncology},
  year={2004},
  volume={31 5},
  pages={595-604}
}
Primary central nervous system (CNS) tumors constitute a small fraction of the overall incidence of human cancer, but they represent a major source of cancer-related morbidity and mortality. The most common CNS tumor subtype in adults, high-grade astrocytoma, confers a dismal prognosis with a median survival of only 1 to 2 years. Other common adult CNS tumors, ie, low-grade astrocytomas and oligodendrogliomas, carry a less ominous, yet still poor prognosis. Unfortunately, there has been little… CONTINUE READING