Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.

@article{Meyer2012AlteredME,
  title={Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.},
  author={Imke Meyer and Stefan Kunert and Silke Schwiebert and Ina Hagedorn and Joseph E. Italiano and Sebastian D{\"u}tting and Bernhard Nieswandt and Sebastian Bachmann and Harald Schulze},
  journal={Blood},
  year={2012},
  volume={120 17},
  pages={
          3594-602
        }
}
The crucial function of blood platelets in hemostasis is to prevent blood loss by stable thrombus formation. This process is driven by orchestrated mechanisms including several signal transduction cascades and morphologic transformations. The cytoplasmic microtubule modulator RanBP10 is a Ran and β1-tubulin binding protein that is essential for platelet granule release and mice lacking RanBP10 harbor a severe bleeding phenotype. In this study, we demonstrate that RanBP10-nullizygous platelets… 
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