Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.

@article{Zhang2012AlteredMR,
  title={Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.},
  author={Bin Zhang and Yin Wei Ho and Qin Huang and Takahiro Maeda and Allen C. Lin and Sung-Uk Lee and Alan Hair and Tessa L Holyoake and Claudia S. Huettner and Ravi Bhatia},
  journal={Cancer cell},
  year={2012},
  volume={21 4},
  pages={577-92}
}
We characterized leukemia stem cells (LSC) in chronic phase chronic myelogenous leukemia (CML) using a transgenic mouse model. LSC were restricted to cells with long-term hematopoietic stem cell (LTHSC) phenotype. CML LTHSC demonstrated reduced homing and retention in the bone marrow (BM), related to decreased CXCL12 expression in CML BM, resulting from increased G-CSF production by leukemia cells. Altered cytokine expression in CML BM was associated with selective impairment of normal LTHSC… CONTINUE READING
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