Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.

@article{Nigam2010AlteredMI,
  title={Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.},
  author={Vishal Nigam and Hans H. Sievers and Brian C Jensen and Holger A Sier and Paul C. Simpson and Deepak Srivastava and Salah Ali Mohamed},
  journal={The Journal of heart valve disease},
  year={2010},
  volume={19 4},
  pages={459-65}
}
BACKGROUND AND AIM OF THE STUDY Bicuspid aortic valve (BAV), the most common form of congenital heart disease, is a leading cause of aortic stenosis (AS) and aortic insufficiency (AI). AS is typically caused by calcific valve disease. Recently, microRNAs (miRNAs) have been shown to modulate gene expression. The study aim was to examine the miRNAs that were altered in the aortic valve leaflets of patients with AS compared to those in patients with AI. In-vitro experiments were also carried out… CONTINUE READING
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