Altered miRNAs expression profiling in sperm of mice induced by fluoride.

@article{Sun2016AlteredME,
  title={Altered miRNAs expression profiling in sperm of mice induced by fluoride.},
  author={Zilong Sun and Wen Zhang and Sujuan Li and Xingchen Xue and Ruiyan Niu and Lei Shi and Baojun Li and Xiaowen Wang and Jundong Wang},
  journal={Chemosphere},
  year={2016},
  volume={155},
  pages={109-114}
}
The reproductive toxicity of fluoride has become a major concern in the world. Fluoride can decrease the abilities of sperm capacitation, hyperactivation, chemotaxis, acrosome reaction and fertilization, but the studies on the responses of sperm small noncoding RNAs (sncRNAs), especially miRNAs, to fluoride exposure are lacking. miRNAs are demonstrated to influence sperm quality and male fertility by regulating gene expression at post-transcriptional levels or translational repression. The… CONTINUE READING