Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.

@article{Lupu2017AlteredMO,
  title={Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.},
  author={Daniel S Lupu and Luz D. Orozco and Ying Wang and John M Cullen and Matteo Pellegrini and Steven H Zeisel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 5},
  pages={2090-2103}
}
Folate B12-dependent remethylation of homocysteine is important, but less is understood about the importance of the alternative betaine-dependent methylation pathway-catalyzed by betaine-homocysteine methyltransferase (BHMT)-for establishing and maintaining adequate DNA methylation across the genome. We studied C57Bl/6J Bhmt (betaine-homocysteine methyltransferase)-null mice at age 4, 12, 24, and 52 wk (N = 8) and observed elevation of S-adenosylhomocysteine concentrations and development of… CONTINUE READING
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