Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines.

@article{Stern1984AlteredMM,
  title={Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines.},
  author={Peter H. Stern and Cynthia D Wallace and Robert M Hoffman},
  journal={Journal of cellular physiology},
  year={1984},
  volume={119 1},
  pages={29-34}
}
Methionine dependence is a metabolic defect found thus far only in transformed and malignant cells. The defect is manifested as the inability of cells to grow in media in which methionine (Met) is replaced by its immediate precursor homocysteine (Hcy). We have termed this Met- Hcy+ media. We demonstrate here that methionine-dependent cells derived from human tumors, compared to normal methionine-independent cells, have low levels of free Met, low levels of S-adenosylmethionine (AdoMet) and… CONTINUE READING

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