Altered metabolic flux due to deletion of odhA causes L-glutamate overproduction in Corynebacterium glutamicum.

@article{Asakura2007AlteredMF,
  title={Altered metabolic flux due to deletion of odhA causes L-glutamate overproduction in Corynebacterium glutamicum.},
  author={Yoko Asakura and Eiichiro Kimura and Yoshihiro Usuda and Yoshio Kawahara and Kazuhiko Matsui and Tsuyoshi Osumi and Tsuyoshi Nakamatsu},
  journal={Applied and environmental microbiology},
  year={2007},
  volume={73 4},
  pages={1308-19}
}
L-glutamate overproduction in Corynebacterium glutamicum, a biotin auxotroph, is induced by biotin limitation or by treatment with certain fatty acid ester surfactants or with penicillin. We have analyzed the relationship between the inductions, 2-oxoglutarate dehydrogenase complex (ODHC) activity, and L-glutamate production. Here we show that a strain deleted for odhA and completely lacking ODHC activity produces L-glutamate as efficiently as the induced wild type (27.8 mmol/g [dry weight] of… CONTINUE READING
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