Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure.

@article{McArthur2005AlteredMD,
  title={Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure.},
  author={Simon McArthur and E Mchale and Jeffrey W. Dalley and Julia C. Buckingham and Glenda E. Gillies},
  journal={Journal of neuroendocrinology},
  year={2005},
  volume={17 8},
  pages={475-82}
}
Early exposure to stressors is strongly associated with enduring effects on central nervous system function, but the mechanisms and neural substrates involved in this biological 'programming' are unclear. This study tested the hypothesis that inappropriate exposure to glucocorticoid stress hormones (GCs) during critical periods of development permanently alters the mesencephalic dopaminergic populations in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). Using a rat… CONTINUE READING

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