Altered meiotic regulation in oocytes from diabetic mice.

  title={Altered meiotic regulation in oocytes from diabetic mice.},
  author={Shannondoah A Colton and Galen M. Pieper and Stephen M Downs},
  journal={Biology of reproduction},
  volume={67 1},
In the present study, we have utilized a streptozotocin-induced diabetic mouse model to examine how the diabetic condition and different glucose concentrations affect several parameters of reproductive physiology. We report that oocyte maturation is altered under all experimental conditions examined. In cumulus cell-enclosed oocytes (CEO) from diabetic mice, spontaneous maturation was accelerated but the FSH-mediated delay of spontaneous maturation was suppressed. Higher glucose levels in the… CONTINUE READING
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