Altered maturation of circulating dendritic cells in primary progressive MS patients

  title={Altered maturation of circulating dendritic cells in primary progressive MS patients},
  author={C L{\'o}pez and Manuel Comabella and Hammad Al-zayat and Mar Tintore and Xavier Montalban},
  journal={Journal of Neuroimmunology},
We investigated the phenotype and frequency of circulating myeloid dendritic cells (MDC) and plasmacytoid DC (PDC) in 86 multiple sclerosis (MS) patients and 33 healthy controls (HC). The MS group comprised 20 patients with primary progressive MS (PPMS), 20 patients with secondary progressive MS (SPMS), and 46 patients with relapsing-remitting MS (RRMS) [23 treated with interferon-beta (IFN-beta)]. The frequency of circulating MDC and PDC, and the expression of CD83, CD123, CD80, CD86, and CD40… CONTINUE READING

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