Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

@inproceedings{Ita2015AlteredLE,
  title={Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome},
  author={Julieta Rodr{\'i}guez De Ita and Inma Castilla-Cortazar and Gabriel Amador Aguirre and C. S{\'a}nchez-Yago and M. Olleros Santos-Ruiz and Luc{\'i}a Guerra-Men{\'e}ndez and Irene Mart{\'i}n-Estal and Mariano Garc{\'i}a-Magari{\~n}o and V. J. Lara-D{\'i}az and Juan Enrique Puche and Ursula Mu{\~n}oz},
  booktitle={Journal of Translational Medicine},
  year={2015}
}
Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin resistance, impairs lipid metabolism, augments oxidative damage and deregulates the neuro-hormonal axis. An inverse relationship between IGF-1 levels and the prevalence of Metabolic Syndrome (MetS) with its cardiovascular complications has been identified. However, the underlying mechanisms linking IGF-1 and MetS are still poorly understood. In order… CONTINUE READING